First 3D structure of an MBOAT enzyme solved

June 27, 2019
JCC Fellow Dan Ma published the work in Nature

The crystal structure of a transmembrane bacterial enzyme responsible for modification of the cell wall was recently solved by JCC Fellow Dan Ma and her colleagues. The enzyme is a type of MBOAT, an important […]

Read More

Small molecules can interfere with dengue virus entry

June 26, 2019
Former JCC Fellow Luke Chao published the research in eLife

Caption: Flavivirus membrane fusion. A) Steps in the fusion transition. Starting point and end point represent known structures; steps in brackets inferred from experimental evidence as summarized in (Chao et al., 2014). B) Scheme for […]

Read More

Q&A with JCC Fellow Yunhao Tan

June 26, 2019
Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

Recent research published in Cell by JCC Fellow Yunhao Tan demonstrates the flexibility and programmability of immune signaling organelles. In this Q&A, Tan explains his work, completed with Jonathan Kagan at Harvard Medical School. Q) […]

Read More

Two Members of the Board of Scientific Advisors Retire This Year

June 26, 2019
Dr. Carol Prives and Dr. Luis Parada retire from the JCC Board this year

The Jane Coffin Childs Fund would like to thank Dr. Carol Prives and Dr. Luis Parada for their years of service to the organization. Carol Prives, the Da Costa Professor in the Department of Cell […]

Read More

Cellular Pressure Sensors Explored

May 1, 2019
JCC Fellow Kei Saotome uncovers structure of a mechanically activated ion channel

Caption: The OSCA1.2 mechanically activated ion channel. Source: Jojoa-Cruz, Saotome, et al, eLife 2018;7:e41845 doi: 10.7554/eLife.41845 (CC-BY-4.0) A punch versus a caress. The feel of Velcro versus silk. Our sense of touch distinguishes between these […]

Read More