Directory - Jane Coffin Childs Memorial Fund

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Year Appointed

Institution

Name

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J. Gregor Sutcliffe Jane Coffin Childs Fellow

Scripps Research Institute

Appointed in 1978

Moloney murine leukemia virus

Hiromi Suzuki Jane Coffin Childs Fellow

Salk Institute for Biological Studies

Appointed in 1966

Mechanisms of biological regulation

Jeffrey Swan, Ph.D. Jane Coffin Childs Fellow

University of Utah /
St. Jude

Appointed in 2023

Mechanism of DNA searching CRISPR-associated transposons

CRISPR-associated transposons (CASTS) enable programmable DNA insertion, yet there is a limited understanding of how they recognize specific DNA sequences and activate DNA insertion. Dr. Jeffery Swan will conduct structural and kinetic studies of CASTs in Dr. Elizabeth Kellogg’s lab at St. Jude Children’s Research Hospital. Dr. Swan will investigate the AAA+ (ATPases Associated with diverse cellular Activities) regulator TnsC which influences both ATP hydrolysis and DNA deformation. He will use cryo-electron microscopy to structurally characterize the fully assembled integration complex, and single-molecule and ensemble kinetic experiments to better understand transpososome assembly and activation. Swan anticipates that these studies will guide future attempts to rationally engineer CASTs for gene-editing and therapeutic applications.

As a Ph.D. student in Dr. Carrie Partch‘s lab at the University of California at Santa Cruz, Swan investigated the role of the KaiC, an AAA+ protein that effectuates circadian timing. Dr. Swan demonstrated that the ATPase activity in KaiC imparts cooperativity to the transition between autophosphorylation and autodephosphorylation, which is an important feature of the circadian clock. With his expertise in AAA+ proteins, Dr. Swan is ready to investigate how TnsC enables the programmable DNA insertion of CASTs.

Jean-Marie Swiecicki Jane Coffin Childs Fellow

Massachusetts Institute of Technology

Appointed in 2016

Interrogating macromolecular interactions at biological membranes

I am passionate about biological processes that occur at cellular membranes. Membranes not only define the borders of cells but also create a fascinating physicochemical environment for a wide diversity of functions. The broad questions that I have been addressing focus on understanding the role of membrane lipids in the function of membrane peptides and membrane protein complexes and developing innovative methods for modulating lipid-peptide or lipid-protein interactions in order to control biological responses._x000D_
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During my graduate research in France under the supervision of Prof. Solange Lavielle and Dr. Fabienne Burlina (at the École Normale Supérieure and the Pierre and Marie Curie University), I studied the spontaneous translocation of peptides through cell membranes that can be used as drug delivery agents. I characterized the translocation event at the molecular level, which provided pertinent clues to the design of drug delivery vectors with enhanced translocation abilities._x000D_
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As a post-doctoral fellow in the laboratory of Prof. Barbara Imperiali (at Massachusetts Institute of Technology), my overarching goal is to decipher the organization and dynamics of supramolecular membrane protein complexes that are part of the N-linked protein glycosylation pathway of pathogenic bacteria. I propose to complement the current methods with an integrated strategy that will merge cell-free membrane protein expression, bioorthogonal labeling and membrane bilayer Nanodiscs. When combined, these technologies will give access to site-specifically labeled membrane-resident protein samples for detailed single-molecule biophysical analysis.

Stuart J. Swiedler Jane Coffin Childs Fellow

Duke University

Appointed in 1987

Structural characterization of mammlian alpha 1, 3-fucosyl-tranferases

Mary H. Sym Jane Coffin Childs Fellow

University of California, San Francisco

Appointed in 1994

Mi9-13 and cell migration

Alexander Symeonidis Jane Coffin Childs Fellow

National Institutes of Health

Appointed in 1948

Supplement to NIH grant

Wlodzimierz Szer Jane Coffin Childs Fellow

New York University

Appointed in 1963

Secondary structure on the messenger function of synthetic polyribonucleotides in protein synthesis

Alexander A Szewczak Jane Coffin Childs Fellow

University of Colorado, Boulder

Appointed in 1994

RNA folding in the tetrahymena group 1 intron

Clifford J. Tabin Jane Coffin Childs Fellow

Harvard University

Appointed in 1984

Control of early development in Xenopus laevis

Michael R. Tadross Jane Coffin Childs Fellow

Stanford University

Appointed in 2010

Optogenetic deconstruction of local calcium signaling domains

Calcium signaling is ubiquitous within cells, with numerous implications for cancer biology. I am developing new molecular tools to study spatiotemporal calcium signaling in neurons and other cell types._x000D_
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My interest in biology originally stemmed from a love for math, engineering, and technology. High-school experiences on the computer team, and during a summer internship where I worked with circuits and radar, hooked me on engineering, and led to an undergraduate major in electrical engineering. However, I had a lingering penchant for biology and, during college, when I was exposed to the field of bioengineering, I realized how engineering and biology were truly compatible with one another. Since then, Ive had the privilege of full-immersion into both biology and technology. I received my MD/PhD at Johns Hopkins where my incredible mentor, David Yue, helped me realize how beautiful complexity can arise from simple interactions present within cells, and how calcium, in particular, acts as a universal currency of information transfer within cells. With JCC fellowship support, I plan to develop tools not only to study, but also manipulate calcium signaling in cells tools that will likely be useful in many branches of biological science.

Michiko E. Taga Jane Coffin Childs Fellow

Massachusetts Institute of Technology

Appointed in 2004

Vitamin B12 in rhizobium-legume symbiosis

Yasuyuki Takagi Jane Coffin Childs Fellow

National Institutes of Health

Appointed in 1955

Nucleic acid synthesis

Peter A. Takizawa Jane Coffin Childs Fellow

University of California, San Francisco

Appointed in 1997

ASH1 mRNA localization in S. cervisiae

William S. Talbot Jane Coffin Childs Fellow

University of Oregon

Appointed in 1993

Molecular analysis of the zebrafish axial patterning gene floating head

John W. Tamkun Jane Coffin Childs Fellow

University of Colorado, Boulder

Appointed in 1985

Trans-acting regulators of homeotic gene function

Yunhao Tan Jane Coffin Childs - Merck Fellow

Boston Children's Hospital /
Harvard University Medical School

Appointed in 2014

Dissecting early host endotoxin sensing mechanisms

My first contact with the field of host and pathogen interaction dated back to the time when I was working at Dr. Feng Shao’s Lab at the National Institute of Biological Sciences, Beijing (NIBS), one of the most prestigious research institute in China.¬†¬† My intern project was to clone and characterize the host substrates of an E3 ubiquitin ligase domain containing effector protein from the vacuolar pathogen Legionella pneumophila. From this experience, I was deeply impressed by the broad array of biochemical mechanisms employed by the bacterial effector proteins to manipulate host functions in order to survive and proliferate inside the host.¬† Furthermore, this experience built up my passion and determination to launch my research journey in host and pathogen interaction.

A year later after my internship, I went on to pursuit my graduate study in Dr. Zhao-Qing Luo¬ís Lab at Purdue University.¬† My research projects have been focused on the manipulation of host membrane trafficking pathways by Legionella effectors. ¬†Specifically, I have discovered that Legionella effector proteins exploited distinct post-translational modification mechanisms, i.e. reversible AMPylation and Phosphorylcholination, to regulate the activities of the host small GTPase Rab1. In summary, these findings highlight the sophisticated nature of host-pathogen interactions and reveals that bacterium has the ability to rewire host signaling events for its own benefit.

Living in the ocean of microorganisms, the innate immune system is the first line of defense to protect host from invading pathogens and to maintain tissue homeostasis.¬† Thus, for my postdoctoral training, I would like to branch out my research focus from microbial pathogenesis into studying the cell biological and biochemical regulatory mechanisms of the host innate immune response.¬† Particularly, I will decipher the spatial-temporal relationships among the earliest cell biological events triggered by endotoxin, such as receptor endocytosis, reactive oxygen production, LC3 associated phagocytosis and SMOC formation.¬† I believe that my proposed research will provide new insights into the previously unexplored area of TLR signaling.

Frederick J. Tan Jane Coffin Childs - HHMI Fellow

University of California, Berkeley

Appointed in 2009

A genomic study of homologous recombination between repetitive elements

I am interested in understanding how genome structure affects genome function and evolution. ¬†I am studying how chromosome organization limits homologous recombination between dispersed repetitive DNA elements.

I owe my scientific curiosity to two people: my father, who always took the time to answer my questions when I was young, and my high school biology teacher, Dr. Daniel Walsh, who had an endless supply of knowledge and enthusiasm about science. I’m pursuing an academic research career because I believe that one-on-one mentoring between a principal investigator and a graduate students is an ideal training forum.

Previously, I was a lot more active in sports, mostly cycling and running. ¬†These days, however, when I’m not working, my life centers around my wife and our two dogs. ¬†I am still trying to fit in that occasional run!

Peilin Tan-Aquino Jane Coffin Childs Fellow

Dana-Farber Cancer Institute

Appointed in 2002

Novel genetic approaches in the study of tumor suppressor VHL

Shiho Tanaka Jane Coffin Childs Fellow

California Institute of Technology

Appointed in 2010

A key to the discovery of new antibacterials: structure determination of an essential bacterial membrane protein, MraY

I grew up in Tokyo, Japan, and came to Los Angeles in 2000 to obtain an undergraduate degree in biochemistry. In my junior year at the ¬†University of California, Los Angeles, I joined the protein expression laboratory under Professor Jeanne Perry’s supervision; there, I was fascinated by x-ray crystallography and decided to go to graduate school to learn more about protein structures and functions. During my¬†graduate study at UCLA, I joined Professor Todd Yeates’ laboratory and determined various structures of shell proteins from bacterial¬†microcompartments. I love southern California and am very happy that I get to stay here to do my post-doctoral work at Caltech.

Weixin Tang Jane Coffin Childs - HHMI Fellow

Harvard University

Appointed in 2016

Development of smart genome-editing agents for targeted therapy

Genetic abnormality is the root cause of many diseases. Canonical therapeutics primarily function by binding to the disease-associated proteins and modulating their activity. The recent advent of programmable sequence-specific endonucleases, however, has raised the possibility of direct manipulation of the corresponding genes and could eventually lead to effective cures of many diseases. The therapeutic potential of genome-editing agents is currently limited due to undesired DNA modifications including activity at off-target DNA sites and activity (on-target or off-target) in cells that are not the target population. My research focuses on developing genome-editing agents responsive to various endogenous and exogenous signals with improved specificity

Mi-Hua Tao Jane Coffin Childs Fellow

Stanford University

Appointed in 1991

A novel vaccine for B-cell lymphoma

Donald F. Tapley Jane Coffin Childs Fellow

University of Oxford, England

Appointed in 1956

Factors controlling metabolism at the cellular and sub-cellular level

Justin W. Taraska Jane Coffin Childs Fellow

University of Washington

Appointed in 2005

Imaging dynamics in CNG ion channels

Andrew Taussig Jane Coffin Childs Fellow

McGill-Montreal General Hospital Research Institute

Appointed in 1961

Tumour viruses

C.P.S. Taylor Jane Coffin Childs Fellow

University of Cambridge, England

Appointed in 1960

Mechanism of action of the hemoprotein enzymes

John M. Taylor Jane Coffin Childs Fellow

Stanford University

Appointed in 1972

Characterization of polyribosome-membrane interaction

Kenneth A. Taylor Jane Coffin Childs Fellow

MRC Center, University Medical School, England

Appointed in 1976

Structure of vertebrate striated muscle

John L. Teem Jane Coffin Childs Fellow

Whitehead Institute for Biomedical Research

Appointed in 1983

Transport of ribosomal proteins to the yeast nucleus

Gary F. Temple Jane Coffin Childs Fellow

Massachusetts Institute of Technology

Appointed in 1972

Control of differentiation and development in eukaryotes

Mabel Tettey, Ph.D. Jane Coffin Childs Fellow

National Institute of Allergy and Infectious Diseases

Appointed in 2023

Sexual recombination and virulence in the success of African trypanosomes

In disease-causing organisms, hybridization allows for the transfer of traits such as virulence and drug resistance. Dr. Mabel Tettey will investigate how hybridization impacts African trypanosomiasis outbreaks caused by the parasite Trypanosoma brucei. Dr. Tettey will assess the degree of hybridization occurring in African trypanosome endemic areas, explore the impact of hybridization on virulence, and identify the key molecules involved in this process. She will conduct these experiments in Dr. Michael Grigg’s lab at the National Institute of Allergy and Infectious Diseases. These studies may enable the development of effective disease control strategies against African trypanosomes.

As a graduate student in Dr. Keith Matthews’ lab at the University of Edinburgh, Tettey examined the function of released peptidases in the transmission of African trypanosomes. Specifically, Dr. Tettey identified the genes that dominate quorum sensing signal in African trypanosomes. With her extensive background in trypanosome biology, Dr. Tettey will now examine the role of hybridization in trypanosome virulence.

Sheila Teves Jane Coffin Childs Fellow

University of California, Berkeley

Appointed in 2014

Bookmarking the chromosomes and its role in cellular memory

Cellular memory can be defined as the ability of a cell to transmit all its identifying functions to daughter cells during cell division. This ability to ¬ëremember¬í identity is crucial to the development of multicellular organisms, as evidenced when cells lose their identity and degenerate or become cancerous. Conversely, our ability to alter cell state, such as the generation of induced pluripotent stem (iPS) cells from differentiated cells, has become a promising therapeutic tool. Therefore, understanding how cells establish, maintain, and change identity will further our understanding of processes central to cellular development, disease progression, and therapy production. One mechanism for cellular memory is the ability to re-establish the transcriptional program following mitosis, which may function through bookmarking, the process of DNA-binding factors marking genes on condensed mitotic chromosomes to facilitate gene expression following mitosis. The main objective of this proposal is to analyze the mechanisms of bookmarking. I outline three independent approaches to characterize quantitatively the mechanisms of bookmarking. Using these approaches, I will test the hypothesis that histone variants and pluripotency factors function as bookmarkers to maintain the stem cell state. Lastly, I will perform an unbiased screen to identify putative bookmarking factors specific to embryonic stem cells.

Marla Tharp, Ph.D. Jane Coffin Childs - HHMI Fellow

Whitehead Institute for Biomedical Research

Appointed in 2021

Sex differences in glioblastoma: a microglia perspective

Cancer affects men and women differently. For example, glioblastoma, the most aggressive form of brain cancer, has a male-biased incidence rate and poorer response to standard treatments in men versus women. My research investigates the genetic and molecular basis of sex differences in glioblastoma from the perspective of microglia, the resident immune cells of the brain. Microglia are a major player in the brain tumor microenvironment and promote tumor growth and metastasis. Using XX and XY human microglia isolated from healthy brain regions and brain tumors, I am identifying sex-biased genes and biological pathways that are responsible for establishing sexually dimorphic brain tumor microenvironments. Further, I am testing how possessing an XX or XY sex chromosome complement drives the observed genome-wide sex-biased gene expression patterns in microglia, in particular, through X-linked genes that aberrantly escape X chromosome inactivation or homologous X-Y gene pairs with imbalanced expression or function. I anticipate that my research will lay the groundwork for more effective and sex-specific treatments for glioblastoma.

Helen P. Thompson Jane Coffin Childs Fellow

Rockefeller University

Appointed in 1948

Electron microscopic study of the mammary tumer inciter

Lynnmarie K. Thompson Jane Coffin Childs Fellow

Massachusetts Institute of Technology

Appointed in 1989

Solild state NMR studies of bacteriorhodopsin

Catherine C. Thompson Jane Coffin Childs Fellow

Carnegie Institute for Science

Appointed in 1990

Mechanism of cell-specific transcriptional activation

Jeremy W. Thorner Jane Coffin Childs Fellow

Stanford University

Appointed in 1972

DNA Polymerase

Clark J.B. Tibbetts Jane Coffin Childs Fellow

University of Uppsala, Sweden

Appointed in 1972

Genome structure of adenovirus

David C. Tiemeier Jane Coffin Childs Fellow

National Institutes of Health

Appointed in 1973

Transcription control of globin synthesis

Alisa C. Tietz Jane Coffin Childs Fellow

New York University

Appointed in 1956

Metabolism of propionic acid in animal tissure

David P. Toczyski Jane Coffin Childs Fellow

University of Washington

Appointed in 1993

Mating partner selection in yeast

Joanne Topol Jane Coffin Childs Fellow

California Institute of Technology

Appointed in 1990

RNA and protein localization in the Drosophila egg

Margaret Torrence, Ph.D. Jane Coffin Childs Fellow

Massachusetts Institute of Technology

Appointed in 2022

Deciphering cell-specific metabolic changes in PDAC

Pancreatic cancer represents 3% of all new cancer cases in the United States, yet it has the worst 5-year survival rate of all cancer types. While many cancer types display durable responses to cancer immunotherapy, which harnesses the cytotoxic activity of the immune system to treat malignancies, immunotherapy has largely failed to treat pancreatic ductal adenocarcinoma (PDAC). The complex tumor microenvironment of PDAC likely underlies the refractory response of PDAC to immunotherapy, including immune checkpoint blockade (ICB). One example of a known mechanism that aids immune evasion by PDAC is the presence of desmoplastic stroma that hinders the infiltration of cytotoxic T cells. In addition to exclusion of immune infiltrate, the cytotoxic T cells that are present within the microenvironment are dysfunctional. Nutrient availability within the tumor environment likely impacts the function of cytotoxic T cells and research in immunometabolism is of growing interest. Understanding cell-specific metabolic changes within GEMMs has been hindered by a lack of mouse models that properly recapitulate the tumor microenvironment and lack of tools able to properly isolate cells in a way that preserves the integrity of the metabolites. My project will use a GEMM of PDAC, congenic markers, and cancer cell-specific surface tags in order to rapidly purify and perform metabolomics of both cancer cells and T-cells. Using this technique, I hope to identify metabolic pathways that are hindering immune cell proliferation and cytotoxic capabilities to reinvigorate the immune microenvironment for tumor control and in response to ICB.