Two Members of the Board of Scientific Advisors Retire This Year
Carol Prives, the Da Costa Professor in the Department of Cell and Molecular Biology at Columbia University, studies the structure and function of the p53 tumor suppressor protein. She discovered that the protein is a transcriptional activator, promoting the transcription of specific genes. She also found that a specific viral protein and mutations commonly found in cancers disrupt p53 binding to DNA, setting the stage for tumor growth. Her laboratory identified novel regulators of Mdm2, the protein that holds p53 in check, and demonstrated how chemotherapy interferes with two of these regulators to benefit the patient. Prives is a member of the National Academy of Sciences, and she has been called a “leading light in basic cancer research” by her peers. She served on the BSA for eight years.