PER cascades

November 14, 2017

Primer Exchange Reaction (PER) cascades enable the autonomous growth of single-stranded DNAs. On the top, a ‘catalytic PER hairpin’ binds a first ‘primer’ (shown as a short grey strand), triggers its elongation with a sequence encoded by the hairpin itself, and releases it to start another cycle with the already extended primer, and so forth, until a long transcript is generated.
Wyss Institute at Harvard University