Presenting the 39th Fellows Symposium
The Jane Coffin Childs Memorial Fund for Medical Research presents the
39th FELLOWS SYMPOSIUM
CHALLENGES IN BIOMEDICAL SCIENCES
RESEARCH FROM THE FELLOWS PERSPECTIVE
Friday, Saturday, Sunday, April 8, 9, & 10, 2016
The Interlaken Inn
Lakeville, Connecticut
Jane Coffin Childs Fund Fellows are at a decision point in their scientific careers; most of them are deciding what lines of research to pursue when they complete their training. This Symposium series was originally conceived to inform the Fund’s Fellows about research in clinical medicine relating to cancer, aspects that have already been advanced, or could profitably be undertaken by available biochemical and molecular approaches. Over the years, the topics have expanded to include other emerging areas of basic and medical research. The aim is to expose the Fellows to the excitement, opportunity, and challenges that exist at the interface between molecular biology and clinical science and elect to direct their research interests towards these problems.
Our fellows’ program is intended to highlight the work of our talented third year fellows at a stage in their career where some will begin the search for an independent research or teaching position. We hope that the symposium will be a valuable opportunity for them to hone their communication skills in front of a diverse audience and for them to share their accomplishments and fields of inquiry with each other, the first- and second-year fellows and the Board. Given the wide range of life science work that will be represented in the symposium, no effort has been made to organize the talks by theme. Rather, each presentation will stand on its own. As in the past, the second year fellows will also have their posters on display throughout the weekend, which have by tradition fostered lively discussions.
On Saturday evening, Dr. Cliff Tabin, Professor and Chair, Department of Genetics, Harvard Medical School, has graciously agreed to speak after dinner. His talk is entitled “The development and evolution of vertebrate morphology”. The audience will be encouraged to participate in a discussion afterwards.
The Poster Session will be held on Friday evening and Saturday afternoon.
The scientific program will feature the following presentations:
Eunyong Park
Roderick MacKinnon, The Rockefeller University
STRUCTURE AND MECHANISM OF CHLORIDE ION TRANSPORT BY CLC CHANNELS
Manasi Bhate
William F. DeGrado, University of California, San Francisco
STRUCTURE AND FUNCTION OF BILAYER STRESS-SENSING TRANSMEMBRANE DOMAINS
Alejandro Burga
Leonid Kruglyak, HHMI, University of California, Los Angeles
A GENETIC PARALLEL BETWEEN FLIGHTLESSNESS EVOLUTION IN THE GALAPAGOS CORMORANT (Phalacrocorax harrisi) AND HUMAN CILIOPATHIES
Manuel Leonetti
Jonathan Weissman, HHMI, University of California, San Francisco
SYSTEMATIC APPROACHES IN HUMAN CELLS TO STUDY SPHINGOLIPID REGULATION BY ORM PROTEINS
Christina Woo
Carolyn Bertozzi, Stanford University
A CHEMICAL GLYCOPROTEOMICS APPROACH TO THE GLOBAL PROFILING OF N- AND O- GLYCOPEPTIDES
Tina Han
Lily Jan, University of California, San Francisco
ELUCIDATING THE MOLECULAR MECHANISM OF PHOSPHOLIPID SCRAMBLING AND ITS ROLE IN EXTRACELLULAR VESICLE GENERATION
Jeffrey Rasmussen
Alvaro Sagasti, University of California, Los Angeles
MAKING AND BREAKING SENSORY AXONS IN THE SKIN
Christine Hagan
Marc W. Kirschner, Harvard Medical School
CHOLESTEROL REGULATES A MITOCHONDRIAL UBIQUITIN LIGASE THAT ALTERS ORGANELLE MORPHOLOGY
Jeffrey Farrell
Alexander F. Schier, Harvard University
SINGLE-CELL RNASEQ UNCOVERS A NEW DAMAGE RESPONSE PROGRAM
Athma Pai
Christopher B. Burge, Massachusetts Institute of Technology
WIDESPREAD SHORTENING OF 3’ UTRs AND INCREASED EXON INCLUSION ARE EVOLUTIONARILY CONSERVED FEATURES OF INNATE IMMUNE RESPONSE TO INFECTION
Joseph Cotruvo, Jr.
Christopher J. Chang, University of California, Berkeley
COPPER IS AN ENDOGENOUS REGULATOR OF cAMP-DEPENDENT LYPOLYSIS
Breann Brown
Tania A. Baker, Massachusetts Institute of Technology
THE STRUCTURAL BASIS FOR ALAS-COFACTOR BINDING CATALYZED BY A AAA+ PROTEIN UNFOLDASE
Ruei-Jiun Hung
Norbert Perrimon, Harvard Medical School
BACTERIA, ATP AND AGING
Kole Roybal
Wendell Lim, University of California, San Francisco
PRECISION CONTROL OF TUMOR-TARGETED T CELL RESPONSES WITH SYNTHETIC NOTCH RECEPTORS
Ethan Greenblatt
Allan C. Spradling, Carnegie Institution for Science
GENETIC DETERMINANTS OF GERMLINE STABILITYY
Bethany Strunk
Lois Weisman, Life Sciences Institute, University of Michigan, Ann Arbor
EVIDENCE FOR STIMULUS-INDUCED ACTIVATION OF THE Fab1-Vac14-Fig4 COMPLEX VIA CONFORMATIONAL REARRANGEMENTS IN Fig4
Jessica Polka
Pamela A. Silver, Harvard Medical School
MECHANISMS AND APPLICATIONS OF RETRACTABLE, MICRON-SCALE, MEMBRANE-BREAKING PROTEIN NEEDLES
Elenoe “Crew” Smith
Stuart Orkin, Boston Children’s Hospital
In vivo DISRUPTION OF Bcl11a DNA REGULATORY ELEMENTS VALIDATES THERAPEUTIC RELEVANCE OF AN ERYTHROID SPECIFIC ENHANCER