The Jane Coffin Childs Memorial Fund for Medical Research (JCC Fund) was established by the Childs Family in 1937, to honor the memory of Jane Coffin Childs. Inspired by the founding purpose to support research into the causes and treatment of cancer, the Fund’s mission has broadened to support fundamental scientific research that advances our understanding of the causes, treatments, and cures for human disease.

Jane Coffin Childs announces 2025 Jane Coffin Childs Fellows!

See our first ever Impact Report!

 

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1700

1700 fellows have been funded since the JCC Fund's inception

23

Former fellows & scientific advisors include 23 Nobel laureates

You

Have a chance to be one of the funded. Apply now!

From the blog

Featured Fellow

Phi Nguyen, Ph.D.

Phi Nguyen, Ph.D.

Columbia University

Major depressive disorder (MDD) is a psychiatric disorder with a lifetime prevalence of ~15% and is the leading cause of disability worldwide1. The societal burden of MDD is immense, causing profound personal suffering and economic loss, which has recently been intensified by the Covid-19 pandemic2. The most effective treatments for MDD, a class of antidepressants called the selective serotonin reuptake inhibitors (SSRIs), are successful in achieving remission, but only in ~40% of patients3. Despite being in use for over 50 years, it remains unknown how SSRIs modulate neural circuit function in patients that achieve remission and where these mechanisms are disrupted in those that do not. Thus, a fundamental question remains: What are cellular and molecular mechanisms that mediate antidepressant response and resistance? Defining the answers to this question could provide fundamental insights into the pathophysiology of MDD and uncover novel substrates for future precision medicine approaches.

 


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