Directory - Jane Coffin Childs Memorial Fund

Status

Year Appointed

Institution

Name

Clear Filters

Richard B. Flavell Jane Coffin Childs Fellow

Stanford University

Appointed in 1967

Hernan A. Flores-Rozas Jane Coffin Childs Fellow

Dana-Farber Cancer Institute /
Ludwig Institute for Cancer Research, La Jolla

Appointed in 1996

Linda S. Folley Jane Coffin Childs Fellow

Cornell University

Appointed in 1988

Jefferson Foote Jane Coffin Childs Fellow

MRC Center, University Medical School, England

Appointed in 1985

Barry M. Forman Jane Coffin Childs Fellow

Salk Institute for Biological Studies

Appointed in 1992

Anthony C. Forster Jane Coffin Childs Fellow

Yale University

Appointed in 1988

Velia M. Fowler Jane Coffin Childs Fellow

National Institutes of Health /
The Johns Hopkins University

Appointed in 1980

Robert O. Fox Jane Coffin Childs Fellow

Oxford University, England /
Yale University

Appointed in 1982

Barbara S. Fox Jane Coffin Childs Fellow

National Institutes of Health

Appointed in 1983

Donald T. Fox Jane Coffin Childs Fellow

Carnegie Institute for Science

Appointed in 2007

Robert T. Fraley Jane Coffin Childs Fellow

University of California, San Francisco

Appointed in 1980

Alison R. Frand Jane Coffin Childs Fellow

Massachusetts General Hospital

Appointed in 2000

Mervyn Franklin Jane Coffin Childs Fellow

Case Western Reserve University

Appointed in 1959

Jeffrey A. Frelinger Jane Coffin Childs Fellow

University of Michigan

Appointed in 1973

John G. Frelinger Jane Coffin Childs Fellow

Stanford University

Appointed in 1981

Gerald D. Frenkel Jane Coffin Childs Fellow

Weizmann Institute of Science, Israel

Appointed in 1971

Adam Freund Jane Coffin Childs Fellow

Stanford University School of Medicine

Appointed in 2012

Melvin Fried Jane Coffin Childs Fellow

Cambridge University, England

Appointed in 1952

Susan J. Friedman Jane Coffin Childs Fellow

Yale University

Appointed in 1971

Jonathan M. Friedman Jane Coffin Childs Fellow

Yale University

Appointed in 1986

Jonathan Friedman Jane Coffin Childs Fellow

University of California, Davis

Appointed in 2012

Robert C. Froemke Jane Coffin Childs Fellow

University of California, San Francisco

Appointed in 2005

Susan Froshauer Jane Coffin Childs Fellow

Yale University School of Medicine

Appointed in 1985

Michelle Fry, Ph.D. Jane Coffin Childs Fellow

Massachusetts General Hospital

Appointed in 2023

Mitochondria generate energy needed to power cells and multicellular organisms. Wrinkles in the inner mitochondrial membrane, known as cristae, concentrate molecular motors for energy production. However, it is unclear how the wrinkly cristae are formed. Dr. Michelle Fry will use a clever approach to investigate cristae formation in cells. She will introduce candidate protein/protein complexes into parasitic protist mitochondria. These mitochondria are smooth, making them amenable for testing with proteins are sufficient to generate cristae. Dr. Fry will use advanced electron microscopy techniques to image changes in mitochondrial morphology. Fry will conduct these studies in Dr. Luke Chao’s lab at Massachusetts General Hospital. These experiments will provide fundamental insights into mitochondrial biology and may provide clues for mitochondrial pathological dysfunction.

As a graduate student in Dr. Bil Clemons lab at the California Institute of Technology, Fry used structural biology to study the targeting of membrane proteins to the endoplasmic reticulum. Specifically, Dr. Fry captured several structural conformations of a protein chaperone, Get3. Fry demonstrated how conformational flexibility is important for Get3 to integrate multiple regulatory signals (binding partners, client proteins, nucleotide binding and hydrolysis). Dr Fry is now excited to use cryo-electron tomography to capture the conformational landscape of proteins that regulate mitochondrial cristae formation in cells.

Margaret T. Fuller Jane Coffin Childs Fellow

Indiana University

Appointed in 1980

Bernard K. Fung Jane Coffin Childs Fellow

Stanford University

Appointed in 1977

Andrew J. Furley Jane Coffin Childs Fellow

Columbia University

Appointed in 1987

Nadezda Fursova, D.Phil. Jane Coffin Childs Fellow

National Cancer Institute / NIH

Appointed in 2021

Enhancers are distal cis-regulatory elements that control precise execution of transcriptional programs during development and in response to external stimuli. How enhancers find and activate their target genes, and what molecular activities are required for enhancer function remains a central outstanding question in the field. Recent advances in nascent RNA-sequencing uncovered widespread transcription from enhancers, which has become widely recognized as a robust signature of enhancer activity. However, mechanistic understanding of enhancer transcription, its regulation and, most importantly, functional role in gene activation is currently missing.
In my work, I aim to address these fundamental questions by using single-molecule and live-cell imaging approaches to characterize the intrinsic dynamics of enhancer transcription in single cells. To generalize my conclusions from individual enhancers to a genome scale, my ultimate goal is to develop high-throughput single-molecule approaches for systematic characterization of enhancer transcription. Using these new tools, I will investigate how transcription at enhancers and their target gene promoters is coordinated at the single-cell level to discover if these processes are functionally linked. Together, this work will be an essential step towards a deeper mechanistic understanding of enhancer function in gene activation and how enhancer perturbations can lead to severe developmental disorders and cancer.

Mark E. Furth Jane Coffin Childs Fellow

MRC Center, University Medical School, England

Appointed in 1978

Deborah K. Fygenson Jane Coffin Childs Fellow

University of Southern California, Los Angeles

Appointed in 1996

Eric A. Galburt Jane Coffin Childs Fellow - Agouron

Lawrence Berkeley National Laboratory /
University of California, Berkeley

Appointed in 2003

Maria E. Gallegos Jane Coffin Childs Fellow

University of California, San Francisco

Appointed in 1998

Alison E Gammie Jane Coffin Childs Fund

Princeton University

Appointed in 1992

Alexandra Gampel Jane Coffin Childs Fellow

University of Cambridge, England

Appointed in 1991

Ninghai Gan Jane Coffin Childs - HHMI Fellow

University of Texas Southwestern Medical Center

Appointed in 2020

Barry S. Ganetzky Jane Coffin Childs Fellow

California Institute of Technology

Appointed in 1976

Margaret L. Gardel Jane Coffin Childs Fellow

Scripps Research Institute

Appointed in 2005

Zev J. Gartner Jane Coffin Childs Fellow

University of California, Berkeley

Appointed in 2006

Shimon Gatt Jane Coffin Childs Fellow

Public Health Research Institute of the City of New York

Appointed in 1955

Elizabeth R. Gavis Jane Coffin Childs Fellow

Whitehead Institute for Biomedical Research

Appointed in 1990

Laura Gaydos Jane Coffin Childs Fellow

Fred Hutchinson Cancer Center

Appointed in 2015

With a high prevalence of sugar in our society, especially in the form of sugar-sweetened drinks, it is important to understand the relationships between sugar metabolism and critical events in cancer progression. Recent research shows that sugar metabolism can promote oncogenesis in cell culture models of breast epithelial cells. This research was done with the sugar glucose, but breast cancer cells also have the unique ability to uptake fructose, while normal breast epithelial cells do not. Fructose and glucose are both simple sugars that are present in equimolar amounts in most of the food we eat. Although fructose is naturally found in fruits and vegetables, it is also added as high fructose corn syrup to many drinks and processed foods. More research needs to be done on how cancer cells respond to conditions with fructose and glucose. I am using breast cancer cell culture models to investigate the effects fructose and glucose have on cancer cell growth. By focusing on differences in regulation of gene expression with exposure to different sugars, we aim to discover the mechanisms fructose uses to fuel cancer cell growth. We hope this work will lead to better informed dietary recommendations for breast cancer patients and those with an increased risk for breast cancer.

Hui Ge Jane Coffin Childs Fellow

Rockefeller University

Appointed in 1991

Liang Ge Jane Coffin Childs Fellow

University of California, Berkeley

Appointed in 2012

XinXin Ge, Ph.D. Jane Coffin Childs Fellow

University of California, San Francisco

Appointed in 2021

Primary visual cortex (V1) receives visual information ascending from the eyes as well as

descending from higher order visual areas. As such, V1 is the first cortical stage of visual processing at the intersection between two major pathways, the bottom-up, feedforward and the top-down, feedback streams of visual information. Despite current advances in understanding the integration of information from feedforward and feedback pathways in V1, our knowledge relative to how single neurons in V1 combine information from different origins to form their responses to visual stimuli remains rudimentary. To investigate this question, we apply advanced volumetric imaging technique to measure populations of excitatory synaptic inputs impinging onto single neurons in V1. Using this approach, we characterize the visual response properties of excitatory synaptic inputs to visual stimuli as well as the spatial organization of synaptic inputs along the dendritic tree of single V1 neurons. The results from this project will provide insights into the input – output relationship of a neuron to visual stimuli, namely how the visual response properties of synaptic inputs impinging onto a given neuron combine to give rise to the response of that neuron to visual stimuli.