Scripps Research Institute
Appointed in 2006
Massachusetts Institute of Technology
Appointed in 1990
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Massachusetts Institute of Technology
Appointed in 1990
Harvard University
Appointed in 1986
Harvard University Medical School
Appointed in 1998
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Harvard University Medical School
Appointed in 1998
University of California, Berkeley
Appointed in 2000
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University of California, Berkeley
Appointed in 2000
Stanford University School of Medicine
Appointed in 2002
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Stanford University School of Medicine
Appointed in 2002
Cold Spring Harbor Laboratory
Appointed in 1993
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Cold Spring Harbor Laboratory
Appointed in 1993
Rockefeller University
Appointed in 1967
California Institute of Technology
Appointed in 2010
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California Institute of Technology
Appointed in 2010
I am investigating mechanisms of mitochondrial fusion within cells. The goal is to gain a better understanding of how mitochondrial dynamics are regulated.
My interest in scientific research began when I was young, and was fostered through participation in research programs and science fairs in junior high and high school. ¬†After completing my bachelor’s degree in biochemical sciences at Harvard University, I worked briefly for a biotechnology company developing treatments for patients suffering from rare genetic disorders. ¬†I then entered an MD/PhD program the University of Texas Southwestern Medical Center, allowing me to conduct basic science research while receiving training in patient care. ¬†I currently conduct research as a postdoctoral fellow at the California Institute of Technology, and plan to establish my own basic science laboratory in the future.
University of California, San Francisco
Appointed in 1998
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University of California, San Francisco
Appointed in 1998
University of California, Berkeley
Appointed in 2016
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University of California, Berkeley
Appointed in 2016
Yale University
Appointed in 1981
Yale University
Appointed in 2004
University of California, San Diego
Appointed in 2015
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University of California, San Diego
Appointed in 2015
Yale University
Appointed in 1963
Rockefeller University
Appointed in 2014
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Rockefeller University
Appointed in 2014
University of California, Berkeley
Appointed in 2015
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University of California, Berkeley
Appointed in 2015
Just like people, cells have to deal with stress. I study how stressed cellular organelles such as mitochondria communicate with the nucleus, and how this stress response is coordinated in normal settings and dysregulated in disease._x000D_
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I studied genetics as an undergraduate at the University of California, Berkeley, and then worked at Sangamo BioSciences to help develop human genome editing with engineered nucleases. I was then an NSF Fellow in the Tetrad PhD program at the University of California, San Francisco, where I worked in Christine Guthries laboratory. There, I studied how pre-mRNA splicing is regulated in particular, how the cell coordinates a pre-mRNAs transcription and its splicing. My interest in how discrete molecular processes are integrated inside the cell continues during my postdoctoral fellowship in Andrew Dillins laboratory, where I am studying a remarkable pathway called the mitochondrial unfolded protein response. In this pathway, nuclear-encoded mitochondrial protein chaperones are upregulated in response to signals from mitochondria experiencing proteotoxic stress. I am using a disease-in-a-dish model that combines human stem cell technology with genome editing approaches.
University of Oregon
Appointed in 1988
Rockefeller University
Appointed in 2011
Harvard University
Appointed in 2015
My research investigates the neural circuits that control instinctive behavior. Previously, my work focused on the innate active sensing behaviors of rodents that dominate exploration and social interactions. This work has led me to focus on questions that involve the nature of the motivational and descending drives that enable animals to generate robust and instinctive motor patterns in the appropriate context. With the expertise of the Dulac Laboratory, I hope to provide insight into these questions by defining the roles of specific, molecularly-defined cell types and neuronal circuit connectivity patterns that relate to such control. I hope to provide a unique perspective that stems from a background in engineering and the neural control of movement.
University of Utah
Appointed in 2019
The ability of cells and organisms to sense and respond to change is fundamentally driven by dynamic interactions between many different types of molecules. Although we understand some of these interactions, there are many to be uncovered.
I am investigating the landscape of RNA-metabolite interactions and their role in gene regulation. Although RNAs and small molecules can form specific and high-affinity interactions, we know effectively nothing of the RNA-metabolite interactome that might be present in eukaryotic cells. Using RNA-structure probing technologies coupled with high-throughput sequencing, I am studying a broad pool of human RNAs in various metabolic contexts, which will uncover the scope of interactions between human RNAs and human metabolites, identify the specific RNA-metabolite interactions that do occur, and allow us to test the role of these interactions in gene regulation. In complement to this approach, we have developed a screening platform to simultaneously measure the affinity between specific RNAs and 450+ human metabolites. This platform has allowed for rapid, targeted screening of viral RNAs that might sense host metabolism via RNA-metabolite interactions and can be applied to any RNA of interest.
Yale University
Appointed in 1988
University of Connecticut Health Center
Appointed in 1975
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University of Connecticut Health Center
Appointed in 1975
University of California, San Francisco
Appointed in 2019
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University of California, San Francisco
Appointed in 2019
Harvard University Medical School
Appointed in 1998
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Harvard University Medical School
Appointed in 1998
University of California, Berkeley
Appointed in 1983
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University of California, Berkeley
Appointed in 1983
University of California, Davis
Appointed in 1958
Harvard University
Appointed in 2015
I received my BS in Biochemistry from Susquehanna University and my Ph.D. in molecular biophysics in Professor Scott Baileys lab at Johns Hopkins University. Broadly speaking, I am interested in exploring the structure-function relationship of biological macromolecules. For my Ph.D. thesis, I used different structural and biochemical methods to investigate the mechanism by which bacteria use their CRISPR immune system to destroy foreign DNA._x000D_
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In my postdoc with Professor Sunney Xie at Harvard University, my research focuses on the effects of chromatin structure on eukaryotic gene expression. More specifically, I am interested in understanding the dynamics of DNA supercoiling at a single-cell level. Outside the lab, I enjoy playing soccer and going on hikes.
Johns Hopkins University /
The Salk Institute for Biological Studies
Appointed in 1995
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Johns Hopkins University / The Salk Institute for Biological Studies
Appointed in 1995
University of Dundee, Scotland
Appointed in 1987
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University of Dundee, Scotland
Appointed in 1987
Yale University
Appointed in 1944
Princeton University
Appointed in 1994
University of Washington
Appointed in 2004
Harvard University
Appointed in 1981
Johns Hopkins University
Appointed in 1998
University of Wisconsin, Madison
Appointed in 1988
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University of Wisconsin, Madison
Appointed in 1988
Yale University
Appointed in 1965
Stanford University /
Massachusetts General Hospital
Appointed in 1968
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Stanford University / Massachusetts General Hospital
Appointed in 1968
Albert Einstein College of Medicine
Appointed in 1966
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Albert Einstein College of Medicine
Appointed in 1966
University of Washington
Appointed in 1978
University of California, San Francisco
Appointed in 2006
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University of California, San Francisco
Appointed in 2006
University of California, Los Angeles
Appointed in 1985
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University of California, Los Angeles
Appointed in 1985
National Institute of Allergy and Infectious Diseases
Appointed in 1993
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National Institute of Allergy and Infectious Diseases
Appointed in 1993
MRC Center, University Medical School, England
Appointed in 1985
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MRC Center, University Medical School, England
Appointed in 1985
Pennsylvania State University
Appointed in 2003
Broad Institute
Appointed in 2017
New methodologies are needed to develop the next-generation of macromolecular human therapeutics that have the potential to improve our ability to treat diseases. Continuous directed evolution techniques such as phage-assisted continuous evolution (PACE) have demonstrated a transformative ability to access_x000D_
biomolecules with therapeutically relevant properties that could not have been readily accessed using conventional protein evolution methods, including improved genome editing agents, and proteases reprogrammed to cleave proteins implicated in human disease. However, PACE is greatly constrained by the requirement that it be performed in Escherichia coli, thereby precluding its application to solve important problems that require eukaryotic infrastructure, such as post-translational modification,_x000D_
chaperones that are not found in E. coli, chromatin editing or modification, subcellular localization, or organelles. I propose to design and execute a system for the continuous evolution of biomolecules in yeast, enabling access to many of these important selections. We will use this system to evolve versions of the E3 ligase MDM2 that exclusively target mutant, but not wild-type p53, for ubiquitination and degradation, demonstrating the power of eukaryotic continuous evolution to evolve proteins that are_x000D_
inaccessible to PACE, as well as generating a novel potential research tools and leads for future cancer therapeutic development.
Fred Hutchinson Cancer Center
Appointed in 2008
Rockefeller University
Appointed in 1976
Albert Einstein College of Medicine
Appointed in 1975
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Albert Einstein College of Medicine
Appointed in 1975
Yale University
Appointed in 1946
University of California, San Francisco
Appointed in 2002
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University of California, San Francisco
Appointed in 2002