Andrew E. H. Elia

Study of regulatory protein modifications in the DNA damage response, with Dr. Stephen J. Elledge

Massachusetts General Hospital Harvard Medical School, Boston, MA

The cellular machinery of the DNA damage response (DDR) consists of a dynamic network of multiprotein complexes whose hierarchical assembly relies upon an array of posttranslational modifications. Dr. Elia is studying novel mechanisms by which such post-translational modifications regulate the DDR.

Dr. Elia attained his Bachelor’s degree in Chemistry from Stanford University before entering an MD/PhD program at Harvard Medical School, where he attained his PhD in the laboratory of Lewis Cantley.  He recently completed his residency in Radiation Oncology at Harvard and is now working in the laboratory of Stephen Elledge. Dr. Elia is interested in genomic instability and how it influences the progression and treatment of cancer.  Numerous cancer susceptibility syndromes arise from the mutation of DNA repair genes, whose loss undermines genomic integrity. The modulation of such DNA repair pathways can also affect tumor sensitivity to radiation and chemotherapy.  Dr. Elia is interested in studying how synthetic lethal interactions between such DNA repair pathways might be exploited in the treatment of cancer.